![]() This restraint is removed at birth, leading to reactivation of the axis and an increase in gonadotropin concentrations. In human beings, the hypothalamic-pituitary-gonadal axis is active in the mid-gestational fetus, but silenced towards the end of gestation. 1 Gonadotropin-releasing hormone (GnRH) is produced in the preoptic area of the hypothalamus and released from axon terminals in the median eminence in a pulsatile manner to stimulate the secretion of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary, which in turn act on the gonads to promote gametogenesis and the production of sex steroids. ![]() Puberty and reproduction are controlled by the hypothalamic-pituitary-gonadal axis. ![]() Puberty is the period of transition between childhood and adulthood, characterised by the development of secondary sexual characteristics, gonadal maturation, and attainment of reproductive capacity.
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